Knee Cartilage Regeneration at Germanten Hospital Hyderabad
Date 3rd August 2019 | Hyderabad | Edited Version |
“ Knee pain from osteoarthritis remains a major cause of disability and missed worked days “ educate Dr Mir Jawad Zar Khan Sir while addressing Hundreds of Osteoarthritis Patients on Friday at GERMANTEN Hospital Hyderabad.
“ Conservative treatment is typically aimed at relieving pain and begins with anti-inflammatory medications, physical therapy and opioid pain medications. Injection therapy with corticosteroids and hyaluronic acid will often be used as the next line of treatment for knee cartilage repair. Surgical treatments such as arthroscopy, subchondral bone drilling and microfracture are often the next steps in the treatment cascade.
Unfortunately, many of these patients continue to progress and eventually undergo knee joint replacement surgery.
Dr Mir Jawad Zar Khan Sir, India’s Top Knee Replacement Surgeon Iodated that “ Stem cell therapy for knees is a minimally invasive procedure that has the potential to decrease inflammation, halt the progression of the arthritic damage, repair joint cartilage, and delay or avoid knee replacement surgery “.
🔴 Articular Knee Cartilage Damage :
Articular cartilage damage, especially when it affects the knee joint, remains a major clinical problem due to the poor intrinsic ability for this tissue to repair itself. The major function of joint cartilage is to allow for smooth gliding of joint surfaces and protect the surrounding bone from stress. This is key for being able to continue doing sports such as skiing. Articular cartilage allows the knee to absorb shock and loads up to 20 times the body weight.
🔴 The Impact of Osteoarthritis :
Osteoarthritis is a chronic degenerative disorder that ultimately leads to a gradual deterioration of knee joint cartilage. Osteoarthritis may also be the result of a prior injury to the knee joint such as a fracture, tendon damage and ligament tears.
This may lead to joint instability which can cause wear and tear to the articular cartilage. Arthritis can affect not only the cartilage but may lead to damage of the bone beneath the cartilage, the synovial lining to the joint, ligaments, tendons, and muscles.
Intra-articular placement of stem cells into right the knee joint with spread into both the medial and lateral joint spaces.
☑ Types of Stem Cells for Degenerative Knee Cartilage :
Injection of progenitor cells, especially mesenchymal stem cells, has been shown to be a better strategy to repair degenerative cartilage than implantation of differentiated cells such as articular cartilage. Adult stem cells have a reliable potential to differentiate into cartilage, bone, fat or soft tissue.
“ They also display the ability to home to areas of inflammation and degeneration, and to modify immune system activity that can favorably influence the surrounding cartilage in areas of damage “ , Says By India’s Top Knee Replacement Surgeon Dr Mir Jawas Zar Khan Sir.
Encouragingly, results of pre-clinical and clinical trials have provided initial evidence of efficacy and safety in the therapeutic use of stem cell therapies for the treatment of knee cartilage damage and osteoarthritis. Cell-based therapy has become a key focus of tissue engineering research focused on functional replacement of cartilage and meniscus regeneration.
Stem Cell Extraction Methods :
Adult stem cells can be extracted by minimally invasive methods from fat tissue and bone marrow.
✔ Bone marrow stem cells have a good potential for differentiation and the concentrated cells have numerous growth factors that aid in the cartilage formation process. Cell numbers in bone marrow unfortunately dramatically decrease as we age and are often ineffective in most older patients.
✔ Fat derived stem cells show an enhanced ability to differentiate into cartilage and are found in dramatically higher numbers than seen in bone marrow. Not only are they typically 500-2000 times more abundant but they don’t decrease as we age. Fat derived cells have been shown to be successfully employed to target cartilage defects and improve osteoarthritis in patient studies. Fat derived adult stem cells have also demonstrated improved outcomes over bone marrow for cartilage repair.
Not all research is favorable to stem cell therapy at this time due to a wide variation in techniques and cell choice from discrepancies in treatment methods. Due to the many ways stem cell therapy is performed, we see that some variations are not as potent as others.
☑ Supplement with PRP or Concentrated Placental Growth Factors :
A minimally invasive procedure to harvest stem cells from both fat and bone marrow and inject the concentrated cells under image guidance can be performed in 2-3 hours. This procedure when supplemented with additional growth factors from platelet rich plasma or concentrated placental growth factors combines the best properties from each source.
☑ Potential Treatment Results :
Clinical outcomes from ongoing and previous studies are very encouraging, demonstrating the ability to improve pain and generate knee cartilage repair Proudly tells Dr Mir Jawad Zar Khan Sir .
Many patients have been able to avoid knee surgery as a result of advanced stem cell therapies – learn more about the results of a stem cell patient Further studies will help to define specific cell and growth factor combinations to maximize cartilage regeneration.
There have been numerous professional athletes that have benefited in recent years from advanced regenerative therapies for orthopedic pain. A well known athletic superstar has undergone fat-derived stem cell procedures on two occasions.
*Individual patient results may vary. Contact us today to find out if stem cell therapy may be able to help you